Toxic Epidermal Necrolysis (TEN): A Severe Cutaneous Adverse Drug Reaction
نویسندگان
چکیده
منابع مشابه
[News in severe clinical adverse drug reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)].
Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening conditions associated with significant morbidity and mortality. They are considered to be part of a spectrum of cutaneous drug reactions, differing only by their extent of skin detachment due to keratinocyte apoptosis. Drugs are assumed as the main cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in mos...
متن کاملToxic epidermal necrolysis (TEN) : a clinical review
Background: Toxic epidermal necrolysis (TEN) is a severe life-threatening condition associatedwith a low incidence but high mortality rate ranging from 25-50%. TEN is characterized by itswidespread skin necrosis with frequent mucous membrane involvement. The pathophysiology ofTEN has yet to be fully understood, however the current understanding involves a limited scope.Objec...
متن کاملA decade of TEN: An update on toxic epidermal necrolysis
Toxic epidermal necrolysis (TEN) was first described by Lyell in 1956 (1). It is a rare condition, with 1.2 cases per million per year (2), and is characterized by a diffuse erythematous rash that progresses to desquamation of a large body surface area. Although TEN is in the clinical continuum of erythema multiforme (EM) and Stevens Johnson syndrome (SJS), biopsy shows complete separation of e...
متن کاملA case report of hydralazine-induced skin reaction: Probable toxic epidermal necrolysis (TEN)
PATIENT Female, 75 FINAL DIAGNOSIS: Hypertensive crisis with multi organ failure Symptoms: Anemia • general weakness • hypokalemia • nausea • tachycardia MEDICATION - Clinical Procedure: - Specialty: Cardiology. OBJECTIVE Unexpected drug reaction. BACKGROUND Skin reactions are common adverse drug reactions and may include angioedema, erythroderma, Stevens-Johnson syndrome, and toxic epide...
متن کاملToxic epidermal necrolysis (TEN) and development of liver abscesses
Pharmacologic hypersensitivities commonly express cutaneous manifestations, and the highest mortality is found in Stevens Johnson’s syndrome and toxic epidermal necrolysis, mostly associated with antibiotics and anticonvulsive drugs. Toxic epidermal necrolysis is related in 80% of cases to pharmacologic hypersensitivity and systemic consequences may be found; hepatic injury has been described, ...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2015
ISSN: 2319-2003
DOI: 10.5455/2319-2003.ijbcp20150236